The Latest Fish Oil Supplementation Failure
May 13th 2021
(Nov 2020, Brian Peskin) Those following my work know my criticisms of fish oil use for CV Disease and other indications. There is no physiologic basis for fish oil, but this hasn’t stopped enough health professionals from recommending fish oil.
The following study was high caliber, long-term with many patients. The study was sponsored by AstraZeneca.
Fish Oil proponents typically claim fish oil study failures are caused from insufficient dosage. When reviewing these studies it is important to understand that with a 1-gram fish oil capsule — with at least 60% active ingredients — amounts to a 600mg dose of the “active ingredients“ EPA and DHA. The brain uses a mere 7.2mg of DHA/day. Therefore, even 1 gram a day of fish oil is an enormous amount.
In the most recent study, the dosage was 4 grams of concentrated fish oil (75% EPA+DHA). These are retro convertible, so, once either EPA or DHA is ingested, the body can switch between them “as needed.” The details:
Study Summary
AstraZeneca’s sponsored the “STRENGTH” Study with its drug ESPANOVA (50-60% eicosapentaenoic acid (EPA) and 15-25% docosahexaenoic acid (DHA)) with 13,000 men and women at high risk for a CV event while currently taking statins. The primary outcome was time to a significant CV event. The placebo was corn oil. The study duration was up to 5 years. Seventy percent (70%) of the patients were diabetic. Patients were included from 22 countries.
The study was terminated early due to failure. In a secondary analysis of “time to atrial fibrillation,” among events in each group, there was an 69% increase in atrial fibrillation in the ESPANOVA leg compared with the corn oil patients.
Key Insights / Deductions
Secondary outcomes:
Atrial fibrillation: 2.2% in the omega-3 CA (143 patients) group vs. 1.3% (84 patients) in the placebo group (p < 0.001)
Gastrointestinal adverse events: 24.7% in the omega-3 CA group vs. 14.7% in the placebo group.
TIMI major bleeding: 0.8% in the omega-3 CA group vs. 0.7% in the placebo group.”
Comment
Fish Oil proponents continue to make excuse after excuse for fish oil’s failure. If they used lipid physiology in their research, they would avoid these entirely predictable failures.
Brian Peskin formulation for Essential Parent Oils is flaxseed oil based, not fish oil. To purchase the original Peskin formula here.